Исследование лечебных и физико-механических свойств наносодержащих биополимерных пленок
Loading...
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
ВГМУ
Abstract
Цель. Исследование влияния компонентного состава и технологических параметров формирования наносодержащих биополимерных пленок на их лечебные и физико-механические свойства. Материалы и методы. Изучали биополимерные пленки для лечения ран, содержащие желатин, поливиниловый спирт, глицерин, молочную кислоту, дистиллированную воду и нанооксид цинка, изготовленные при различных технологических режимах. Исследовали эластичность, время деградации, паропроницаемость пленок. Лечебные свойства пленок оценивали по результатам измерения диаметра защитного действия. Результаты. Лечебные свойства биополимерной пленки напрямую связаны с диаметром защитного действия. Исследованиями установлено, что диаметр защитного действия пленок, содержащих нанооксид цинка, растет как при увеличении соотношения концентраций компонентов смеси, так и при увеличении содержания нанооксида цинка, достигая при его содержании 197 мг максимума – 20,5 мм. Увеличение времени выдержки при нагревании сначала приводит к снижению диаметра защитного действия, который достигает минимума, а в дальнейшем несколько увеличивается. Увеличение температуры нагревания отрицательно влияет на лечебные свойства пленки, что связано с уплотнением ее структуры. Время деградации пленки растет с увеличением соотношения концентраций компонентов, содержания нанооксида цинка и температуры нагревания смеси. Исследовано влияние состава и режимов получения биополимерной пленки на эластичность, время деградации и паропроницаемость. Введение в состав пленки нанооксида цинка сначала увеличивает ее паропроницаемость, которая после достижения максимума снижается. Биополимерная пленка ? экологически безопасна, в результате ее деструкции выделяется вода и углекислый газ. Нанооксид цинка ? слаботоксичное, неагрессивное соединение, присутствует в незначительном количестве в связанном состоянии в продуктах деструкции пленки. Заключение. Проведенные исследования показали, что лечебные свойства биополимерных пленок зависят от концентрации в них частиц нанооксида цинка. Деградация пленок обеспечивает дозированную доставку лекарств в область поражения.
Objective. To investigate the influence of component composition and technological parameters of the formation of nano-containing biopolymer films on their therapeutic and physico-mechanical properties. Methods. The authors studied nano-containing biopolymer films for wound treatment, which had contained gelatin, polyvinyl alcohol, glycerol, lactic acid, distilled water and zinc nano oxide with various technological mode manufactured. The studied options were as follows: elasticity, degradation time, vapor permeability of biopolymer films. Therapeutic properties of biopolymer films were evaluated based on the results of measuring the protective action diameter. Results. The biopolymer film treatment properties are directly related to the diameter of the protective action. It has been defined that protective effect diameter of films containing zinc nanooxide increases both with an increase in the ratio of the concentrations of the components of the mixture and with an increase in the content of zinc nanooxide, reaching a maximum protective action diameter of 20.5 mm with its content of 197 mg. Thermostat exposition period increasing leads to protective action diameter decreasing reaching a minimum, and in the future slightly increases. The increase in the heating temperature adversely affects the therapeutic properties of the film, which is due to the compaction of its structure. The film degradation time increases with increase of component concentration ratio, the zinc nanooxide concentration and the mixture heating temperature. Component composition and biopolymer film obtaining regimes and their influence on elasticity, degradation time and vapor permeability were studied. Introduction of zinc nanooxide into the composition of the film increases firstly its vapor permeability, which, after reaching the maximum, decreases. Biopolymer film is environmentally safe, water and carbon dioxide are released in its destruction. Nano-oxide of zinc is a weakly toxic, non-aggressive component, present in the products of destruction of the film in the bound state and insignificant amount. Conclusions. Carried out studies have shown that the treatment properties of biodegradable polymeric materials depend on zinc nanooxide concentration, and their degradation properties provide metered delivery of the medicament to the lesion area.
Objective. To investigate the influence of component composition and technological parameters of the formation of nano-containing biopolymer films on their therapeutic and physico-mechanical properties. Methods. The authors studied nano-containing biopolymer films for wound treatment, which had contained gelatin, polyvinyl alcohol, glycerol, lactic acid, distilled water and zinc nano oxide with various technological mode manufactured. The studied options were as follows: elasticity, degradation time, vapor permeability of biopolymer films. Therapeutic properties of biopolymer films were evaluated based on the results of measuring the protective action diameter. Results. The biopolymer film treatment properties are directly related to the diameter of the protective action. It has been defined that protective effect diameter of films containing zinc nanooxide increases both with an increase in the ratio of the concentrations of the components of the mixture and with an increase in the content of zinc nanooxide, reaching a maximum protective action diameter of 20.5 mm with its content of 197 mg. Thermostat exposition period increasing leads to protective action diameter decreasing reaching a minimum, and in the future slightly increases. The increase in the heating temperature adversely affects the therapeutic properties of the film, which is due to the compaction of its structure. The film degradation time increases with increase of component concentration ratio, the zinc nanooxide concentration and the mixture heating temperature. Component composition and biopolymer film obtaining regimes and their influence on elasticity, degradation time and vapor permeability were studied. Introduction of zinc nanooxide into the composition of the film increases firstly its vapor permeability, which, after reaching the maximum, decreases. Biopolymer film is environmentally safe, water and carbon dioxide are released in its destruction. Nano-oxide of zinc is a weakly toxic, non-aggressive component, present in the products of destruction of the film in the bound state and insignificant amount. Conclusions. Carried out studies have shown that the treatment properties of biodegradable polymeric materials depend on zinc nanooxide concentration, and their degradation properties provide metered delivery of the medicament to the lesion area.
Description
НАНОСОДЕРЖАЩИЕ МАТЕРИАЛЫ
БИОПОЛИМЕРНЫЕ ПЛЕНКИ
РАНЫ И ТРАВМЫ /ТЕР
ЦИНКА СОЕДИНЕНИЯ
ФИЗИКО-МЕХАНИЧЕСКИЕ СВОЙСТВА
БИОПОЛИМЕРЫ /ТЕР ПРИМ
ЛЕЧЕБНЫЕ СВОЙСТВА
ЦИНКА НАНООКСИД
КОМПОНЕНТНЫЙ СОСТАВ
БИОПОЛИМЕРНЫЕ ПЛЕНКИ
РАНЫ И ТРАВМЫ /ТЕР
ЦИНКА СОЕДИНЕНИЯ
ФИЗИКО-МЕХАНИЧЕСКИЕ СВОЙСТВА
БИОПОЛИМЕРЫ /ТЕР ПРИМ
ЛЕЧЕБНЫЕ СВОЙСТВА
ЦИНКА НАНООКСИД
КОМПОНЕНТНЫЙ СОСТАВ
Keywords
Citation
Исследование лечебных и физико-механических свойств наносодержащих биополимерных пленок / О. Я. Попадюк [и др.] // Новости хирургии. - 2019. - Т. 27, № 1. - С. 16-25.